Breakdown of myelin insulation in brain's wiring implicated in childhood developmental disorders

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The findings were presented Tuesday at the annual meeting of the American Neurological Association, in Washington, D.C. In healthy individuals, damage to myelin repairs itself naturally. But in people with MS and other disorders of the central nervous system, myelin repair occurs either slowly or not at all. As a result, the flow of information between the brain and the rest of the body is impaired, resulting in movement problems.

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Evidence of myelination as neural Achilles' heel grows

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New evidence points to production of myelin, a fatty insulation coating the brain's internal wiring, as a neural Achilles' heel early in life.

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An upcoming application of a novel model of human brain development and degeneration pioneered by a UCLA neuroscientist identifies disruption of myelination as a key neurobiological component behind childhood developmental disorders and addictive behaviors. rubatex pipe
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Detailed in an article in press with the upcoming annual peer-reviewed publication Adolescent Psychiatry (Hillsdale, N.J.; The Analytic Press Inc.; 2005) the analysis suggests that many factors can disrupt myelination and contribute to or worsen disorders such as autism, attention deficit/hyperactivity disorder and schizophrenia. rubatex 180
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In addition, the analysis suggests that alcohol and other drugs of abuse have toxic effects on the myelination process in some adolescents, contributing to poor treatment outcomes and exacerbating co-existing psychiatric disorders. rubatex 1800
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Author Dr. George Bartzokis, a professor of neurology at UCLA's David Geffen School of Medicine, concludes that the high incidence of impulsive behaviors that characterize the teen years as well as many psychiatric disorders that occur in the teens and 20s are related to incomplete myelination of inhibitory "stop" brain circuits, while the "go" circuits become fully functional earlier in development. These inhibitory circuits are not on line to quickly interrupt high-risk behaviors that are so prevalent in teens and young adults. rubatex 373
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"Myelination, a process uniquely elaborated in humans, arguably is the most important and most vulnerable process of brain development as we mature and age," said Bartzokis, who directs the UCLA Memory Disorders and Alzheimer's Disease Clinic and the Clinical Core of the UCLA Alzheimer's Disease Research Center. rubatex tape
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"Environmental toxins, genetic predispositions and even diet appear to influence and sometimes disrupt this process," he added. "By shifting our research focus to medications that act on brain metabolism and development, as opposed to brain neurotransmitter chemistry, neuroscientists will likely find a wealth of novel opportunities for addressing the cause of brain disease rather than simply the symptoms." rubatex closed cell gasketing
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Myelin is a sheet of lipid, or fat, with very high cholesterol content - the highest of any brain tissue. The high cholesterol content allows myelin to wrap tightly around axons, speeding messages through the brain by insulating these neural "wire" connections. poly products supplies
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Bartzokis' analysis of magnetic resonance images and post-mortem tissue data suggests that the production of myelin is a key component of brain development through childhood and well into middle age, when development peaks and deterioration begins (Neurobiology of Aging, January 2004). He also identifies the midlife breakdown of myelin as a key to onset of Alzheimer's disease later in life (Archives of Neurology, March 2003; Neurobiology of Aging, August 2004). shoreline 13171 17 neoprene
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"This model of a lifelong trajectory of brain development and degeneration embraces the human brain as a high-speed Internet rather than a computer," Bartzokis said. "The speed, quality, and bandwidth of the connections determine the brain's ability to process information, and all these depend in large part on the insulation that coats the brain's connecting wires." neoprene seat covers

University of California-Los Angeles