UCSD Research May Lead to Targeted Treatment for Asthma Sufferers

November 29, 2005 foam insulation

A new type of treatment targets a class of immunoglobulins called immunoglobulin E, which activates mast cells and other inflammatory cells that trigger asthma attacks. Several trials have demonstrated the promise of this product in allergic asthma activity and as a therapy that may help patients reduce or avoid corticosteroids (Boushey HA Jr 2001). It is designed for use in moderate to severe asthma only. Side effects, which may be serious, include allergic reactions, hypotension (low blood pressure), arthritis, and kidney failure.

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The bronchial tubes of a patient with severe asthma can become scarred due to repeated episodes of allergic inflammation in the airways. The scarring results in blocked airways, excessive production of mucus, and shortness of breath.

The research site is in Salt Lake City, Utah. Please see //www.centerwatch. cat310.html. Allergies & Asthma related asthma with standard treatments, you may be eligible for this clinical research study to evaluate the safety and effectiveness of an investigational drug in combination with your current treatment. Study medications will be provided, and you may receive reimbursement for time and travel.

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Researchers at the University of California, San Diego (UCSD) School of Medicine have discovered that when a single gene - IKK beta - is selectively inactivated in the membrane-lining cells of the bronchial tubes of mice that later inhale allergens, such scarring, mucus production and airway inflammation is significantly reduced.

The incidence of asthma is rising dramatically in the United States and across the globe. Asthma affects 17 million people in the U.S. and is the most common chronic childhood disease. If you or someone you love suffers from asthma, you know that there is no cure—however, with proper care, asthmatics can lead normal, active, and fulfilling lives. English guide, which clearly explains the prevention, diagnosis, symptoms, and treatment of the disease.

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Air Humidifiers Humidity Relative humidity under 30% can be very uncomfortable and may also lead to aggravation of asthma symptoms.

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David H. Broide, M.B.,Ch.B., Professor in UCSD's Department of Medicine, and Michael Karin, Ph.D., Professor in UCSD's Department of Pharmacology and the Laboratory of Gene Regulation and Signal Transduction, will publish their findings in the December 6 issue of the Proceedings of the National Academy of Sciences. rubatex msds
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"This finding is significant because it suggests that if we can produce a drug that inhibits IKK beta - for example, a drug that is inhaled to target only the patient's bronchial tubes and not their immune cells - then the scarring, inflammation, and mucus production in asthma could be significantly reduced," said Broide. rubatex pipe
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IKK beta is a master regulator gene that is expressed in cells throughout the body including cells lining the bronchial tubes and immune cells, which are needed to fight infection. Through its effects on the transcription factor NF-kB, IKK beta also regulates the expression of many additional genes important to the induction of airway inflammation in asthma. rubatex 180
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Using gene-targeting strategies, the UCSD team selectively inactivated the IKK beta gene only in the mouse airway membrane-lining cells, called epithelial cells, but not in other cells outside the airway that also express the gene, such as immune cells. The researchers were able to demonstrate that mice lacking the IKK beta gene in these lining cells had significantly less airway inflammation, mucus production and scarring of bronchial tubes after repeatedly inhaling an allergen. rubatex 1800
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The researchers set out to explore selective inactivation of IKK beta in the airway because blocking IKK beta throughout the body to prevent the damaging effects of asthma could also suppress the patient's immune system, resulting in infections. rubatex 373
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"An inhaled IKK beta antagonist could theoretically be designed that would not be absorbed into the blood stream, where it would affect the patient's immune cell function. Such a selective targeting of the drug to the airway would be able to reduce airway inflammation, mucus production, and scarring of the bronchial tubes, with reduced potential for negative side effects." said Broide. rubatex tape
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While only about 10 percent of asthma patients have severe symptoms which lead to scarring of the bronchial tubes, new therapies to prevent scarring are needed, since these patients account for about half of the health costs associated with asthma. As patients with Chronic Obstructive Pulmonary Disease also suffer from mucus production and scarring of their lungs, an inhaled IKK beta antagonist could potentially prove beneficial in such patients. rubatex closed cell gasketing
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This research was funded by a National Institutes of Health grant from the National Institute of Allergy and Infectious Diseases, and a grant from the Sandler Program for Asthma Research. Additional contributors to the paper include members of the Broide Laboratory, Jae Youn Cho, M.D., Ph,D,; Marina Miller, M.D., Ph.D.; Taylor Doherty, M.D.; Kirsti McElwain, B.S.; and Shauna McElwain, B.S., and Toby Lawrence, Ph.D. a visiting scientist in the Karin laboratory. poly products supplies

University of California, San Diego